Peter Diamandis: How to Harness the Power of Mindset in The Longevity Guidebook

I've done about a dozen podcasts in the past few years about anti-aging and longevity—how to live to be 10,000 years old or whatever. Some great episodes with Brian Johnson (who spends $2 million a year trying to reverse his aging), David Sinclair (author of Lifespan and one of the top scientists researching aging), and even Tony Robbins and Peter Diamandis, who co-wrote Life Force. But Peter just did something incredible.

He wrote The Longevity Guidebook, which is basically the ultimate summary of everything we know about anti-aging. If he hadn’t done it, I was tempted to, but he knows everything there is to know on the subject. He’s even sponsoring a $101 million XPRIZE for reversing aging, with 600 teams competing, so he has direct insight into the best, cutting-edge research.

In this episode, we break down longevity strategies into three categories: common sense (stuff you already know), unconventional methods (less obvious but promising), and the future (what’s coming next). And honestly, some of it is wild—like whether we can reach "escape velocity," where science extends life faster than we age.

Peter’s book lays out exactly what’s possible, what we can do today, and what’s coming. So let’s get into it.

Peter Diamandis joins James to talk about the future of human longevity. With advancements in AI, biotech, and medicine, Peter believes we're on the verge of a health revolution that could drastically extend our lifespans. He shares insights from his latest book, The Longevity Guidebook, and discusses why mindset plays a critical role in aging well.

They also discuss cutting-edge developments like whole-body scans for early disease detection, upcoming longevity treatments, and how AI is accelerating medical breakthroughs. Peter even talks about his $101 million XPRIZE for reversing aging, with over 600 teams competing.

If you want to live longer and healthier, this is an episode you can't afford to miss.

Why mindset is a crucial factor in longevity and health
The latest advancements in early disease detection and preventative medicine
How AI and biotech are accelerating anti-aging breakthroughs
What the $101 million XPRIZE is doing to push longevity science forward
The importance of continuous health monitoring and personalized medicine

[00:01:30] Introduction to Anti-Aging and Longevity
[00:03:18] Interview Start – James and Peter talk about skiing and mindset
[00:06:32] How mindset influences longevity and health
[00:09:37] The future of health and the concept of longevity escape velocity
[00:14:08] Breaking down common sense vs. non-common sense longevity strategies
[00:19:00] The importance of early disease detection and whole-body scans
[00:25:35] Why insurance companies don’t cover preventative health measures
[00:31:00] The role of AI in diagnosing and preventing diseases
[00:36:27] How Fountain Life is changing personalized healthcare
[00:41:00] Supplements, treatments, and the future of longevity drugs
[00:50:12] Peter’s $101 million XPRIZE and its impact on longevity research
[00:56:26] The future of healthspan and whether we can stop aging
[01:03:07] Peter’s personal longevity routine and final thoughts