#517 DIGEST: Weight regain after weight loss medications, GLP1/GIP comparisons, valacyclovir for Alzheimer’s, and nudges to encourage deprescribing
16 March 2026

#517 DIGEST: Weight regain after weight loss medications, GLP1/GIP comparisons, valacyclovir for Alzheimer’s, and nudges to encourage deprescribing

The Curbsiders Internal Medicine Podcast

About

Join us as we review and appraise recent practice-changing articles. In this episode, we cover the latest in GLP-1s and GIP agonists for CVD, Type 2 Diabetes, and Obesity, valacyclovir to treat Alzheimer’s, weight regain patterns after medication-induced weight loss, and a deep dive into the data behind deprescribing – and behavioral science to increase deprescribing behavior.  Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Alex Chaitoff (@alexchaitoff), Nora Taranto (@norataranto), & Matt Watto (@doctorwatto).

Claim CME for this episode at curbsiders.vcuhealth.org!

Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME

Credits


    Written and Hosted by: Nora Taranto MD, MSCE; Alexander Chaitoff MD, MPH; Paul Williams, MD, FACP,, & Matthew Watto MD, FACP
    Cover Art: Nora Taranto MD, MSCE
    Reviewer: Sai S Achi MD, MBA, FACP
    Technical Production: Pod Paste
    Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP



Show Segments


    Intro, disclaimer
    GLP-1 + GIPs vs GLP-1s for patients with T2DM and Obesity – SURPASS-CVOT 
    Weight Regain after Weight loss 
    VALAD – Valacyclovir in patients with early Alzheimer’s 
    Nudges to increase Deprescribing 
    Outro


Sponsor:
MedStudy Qbank 

Study less. Remember more. Pass confidently.
Medstudy.com/Curbsiders
CURB15 for 15% off

Sponsor: FIGS

We’ve teamed up with FIGS, and now Curbsiders listeners can get 15% off at Wearfigs.com with code FIGSRX


Sponsor:
Quince

Right now, go to Quince.com/curb for free shipping and 365-day returns. 


Sponsor:
A Dangerous Diagnosis

To get 20% off use DIAGNOSIS20 at www.penguinrandomhouse.com/books/808848/a-dangerous-diagnosis-by-shantanu-rai/paperback/