The Big 4 Weight Loss Drugs Ozempic, Wegovy, Zepbound, Mounjaro. What are the long term effects?
06 October 2025

The Big 4 Weight Loss Drugs Ozempic, Wegovy, Zepbound, Mounjaro. What are the long term effects?

America's Healthcare Advocate

About

I've wanted to do this show for a long time. It's personal to me. This is on what I call the big four weight loss drugs. Ozempic, Wegovy, Zepbound and Mountjaro. And the reason I wanted to do this show was because I was struggling with some weight issues and went to see my primary care doc, and she goes, well, let's just go ahead and give you Wegovy. And I thought, you know, I think I'm going to go find a weight loss clinic. I'm going to get into a program and see what I can do. And I did. So I’ll let you know how that went, but also that it made me think about these products and I started doing a little research, started looking around, and I'm like, you know what?

We don't know what we don't know. And it gave me, some significant hesitation about using these, so this show today is about that. It's about what do we know? What don't we know?

What do we know that are side effects, potential problems down the road for other kinds of diseases and comorbidities because most studies go back only 3.5 years or less. Some additional questions are: What are the long-term effects and what happens if you’re on them on them for a lifetime?

I’ll also review the manufacturer country Green List, so if you are getting one of these from another country to save cost, which are considered safest. We have the research, and I'll lay it out in detail in this episode and I’ll let you know what I think. The studies we've referenced are listed below.

This is episode 2129 of America's Healthcare Advocate. I'm Cary Hall. As always, if you need help or have something to share contact me with this form on my website and let me know what's on your mind, issues you are dealing with, or other health, healthcare, and health insurance questions and concerns. Visit: https://www.americashealthcareadvocate.com/contact-us

Episode Producers:

Audio: Garner Cowdry

Camera: David Thiessen

Research - Nathan Haldeman

Research links for this episode went over the character limit here, so we have posted them here:

https://www.americashealthcareadvocate.com/the-big-4-weight-loss-drugs-ozempic-wegovy-zepbound-mounjaro-what-are-there-long-term-effects